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The guys try to restore the super powers of Spider-Man, Iron Man, Thor and Hulk after Doofenshmirtz's power-draining "inator" zaps them. Meanwhile, Red Skull, Whiplash, Venom and M.O.D.O.K. take advantage of the situation and create mayhem in Danville.
The guys and the gang host a global summer concert, but Doof's latest invention moves the Earth and puts summer itself in jeopardy. Meanwhile, Major Monogram is fired from O.W.C.A., and an evil organization seizes the opportunity to further its agenda.