- Is of Cuban and Italian descent.
- Lived in Puerto Rico for several years as a child, after his parents were divorced.
- Made his stage debut in The Normal Heart at the Duo Theatre in New York in 1994.
- Prepared for his role as paramedic Bobby Caffey on Third Watch by training for two months with real medical personnel.
- Accidentally punched fellow actor Wallace Shawn during a performance of the 2005 revival of Hurlyburly.
- Made his Broadway debut in 2007 in the play Mauritius.
- Was set to play Nicky Arnstein in the 2012 Broadway revival of Funny Girl, but the show was canceled.
- 2013, Emmy — Outstanding Supporting Actor in a Drama Series: Winner
- 2005, Emmy — Outstanding Guest Actor in a Comedy Series: Winner
- 2012, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Drama Series: Nominee
- 2003, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- 2012, Screen Actors Guild Awards — Outstanding Performance by an Ensemble in a Comedy Series: Nominee
- 2013, Emmy — Outstanding Guest Actor in a Comedy Series: Nominee
- 2008, Tony — Actor (Featured Role--Play): Nominee
- 2011, Tony — Actor (Play): Nominee
- 2012, Emmy — Outstanding Guest Actor in a Comedy Series: Nominee
- Isabel — Mother
- Jenny Lumet — Ex-wife
- Rose Byrne — Significant Other
- Rocco Robin Cannavale — Son
- Sal Cannavale — Father
- Annabella Sciorra — Ex-significant Other
- Sutton Foster — Ex-significant Other
- Jake Cannavale — Son
- Birth Place: Union City, New Jersey, United States
- Profession: Actor
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