- Of Greek descent; his grandparents changed their last name from Zanikopoulos to Zane.
- Film debut was in Back to the Future (1985) as Match, one of Biff's thugs.
- International attention came in 1989 for his villainous turn in the thriller Dead Calm, costarring Nicole Kidman and Sam Neill.
- Television performances include the role of John Justice Wheeler in the cult classic Twin Peaks.
- Appears as a partying record executive in the Marilyn Manson video "The Dope Show" and was featured in the Staind video "Epiphany."
- Best-known character is Cal Hockley, the nemesis of Leonardo DiCaprio's Jack in the blockbuster Titanic (1997).
- Made West End theater debut in 2006 opposite Claire Bloom in Six Dance Lessons in Six Weeks.
- 1997, Screen Actors Guild Awards — Outstanding Performance by a Cast in a Motion Picture: Nominee
- Eva Katerina Zane — Daughter
- Karina Lombard — Ex-significant Other
- Leonor Varela — Ex-fiancée
- Lisa Zane — Sister
- William George Zane Sr. — Father
- Thalia Zane — Mother
- Kelly Brook — Ex-fiancée
- Lisa Collins — Ex-wife
- Emma Howard — Ex-significant Other
- Jasmina Hdagha — Significant Other
- Birth Name: William George Zane Jr.
- Birth Place: Chicago, Illinois, United States
- Profession: Actor
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