- Studied ministry as a young man.
- Became a high-school music teacher after graduating from college.
- Met Don Knotts in 1955 when they appeared together on Broadway in No Time for Sergeants.
- Made film debut in 1957 in Elia Kazan's A Face in the Crowd.
- Continued performing, along with Dolores Gray, and kept the Broadway audience calm while firemen put out a backstage blaze during a 1959 matinee of Destry Rides Again.
- Never received an Emmy nomination for The Andy Griffith Show or Matlock.
- Received the 2005 Presidential Medal of Freedom "for demonstrating the finest qualities of our country and for a lifetime of memorable performances that have brought joy to millions of Americans of all ages."
- Inducted into the Christian Music Hall of Fame in 2007.
- Authored the autobiography I Appreciate It: My Life in 2009. Ron Howard penned the foreword.
- 1956, Tony — Actor, Supporting or Featured (Dramatic): Nominee
- 1996, Grammy — Best Southern, Country, or Bluegrass Gospel Album: Winner
- 1960, Tony — Actor (Musical): Nominee
- 1987, People's Choice Awards — Favorite Male Performer in a New TV Program: Winner
- 1981, Emmy — Outstanding Supporting Actor in a Limited Series or Special: Nominee
- Nancy Griffith — Daughter
- Carl Lee Griffith — Father
- Andrew Samuel Griffith Jr. — Son
- Cindi Knight — Wife
- Geneva Griffith — Mother
- Barbara Edwards — Ex-wife
- Dixie Griffith — Daughter
- Solica Cassuto — Ex-wife
- University of North Carolina, Chapel Hill, NC (BA in Music, 1949)
Season 3, Episode 29
- Birth Name: Andrew Samuel Griffith
- Birth Place: Mount Airy, NC
- Birthday: June 1, 1926, Gemini
- Died: July 3, 2012
- Profession: Actor, Producer, Singer, Writer