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Callie (Sara Ramirez), Grey's Anatomy
If Callie's introduction seemed a bit forced, it's because it was. After seeing Ramirez in Spamalot, the network offered her a role any ABC show and a few months later Callie Torres was born. The literal basement dweller and public urinater came into the show as a love interest for George, initially driving a wedge between him and his friends. But once Grey's dropped the contrived romance, we got to see the goofy, compassionate side of Callie and never looked back.