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After an adorable turn in E.T. when she was 6 years old, things went downhill for Barrymore. The actress experimented with alcohol, marijuana and cocaine by the time she entered rehab for the first time at age 13. She returned to rehab after a suicide attempt the following year. After successfully filing for emancipation from her parents as a teen, Barrymore continued acting and posed nude for Interview at age 17 and Playboy at age 19. The actress eventually got on the straight and narrow and has stayed there for the past decade-plus, founding her own production company and starring in a number of box office hits.