Christina Applegate and Will Arnett

With Kevin (Jason Lee) out of the picture, Ava (Maya Rudolph) is looking for love! Unfortunately for Reagan (Christina Applegate) and Chris (Will Arnett), she may have found it in the overly excitable Jerry (Rob Huebel), who also happens to be Chris' much-loathed college roommate.

Up All Night 2.0: Love it or leave it?

So what happens when the newly dubbed "Four Horsemen" go on a double date? Why, hilarity — and tons of eye rolls — ensue, of course!

Check out this first look at Thursday's Up All Night, which airs at 8:30/7:30c on NBC: