Jensen Ackles and Jared Padalecki, Supernatural

What's the difference between angels and demons? Will Sam ever reunite with his mother? Does Dean have more to tell about Hell? Why is Ruby so "different"? And what's coming up that is more than intense? Supernatural supervising producer Sera Gamble made time this week to answer a second batch of TVGuide.com reader questions. So sit back and gain even more insight into the CW's spooktacular series (airing Thursdays at 9 pm/ET).

I'm sure one or two of those people Dean tortured in Hell weren't demons, but regular folk who had an error in judgment. Will Sam and Dean ever run into any of them? — K.
Sera Gamble: We batted around a few versions of that idea, but we've been focusing more on his torturer, Alastair. The pertinent details of Dean's Hell story get told through that relationship. There's more to come in a future episode.

Is Eric going to be directing a episode in the last half of the season? — SherryLynn75
Gamble: Eric is directing the season finale.

I read the spoilers for Episode 18. Is there any chance you will play the character named Sera? — ckll
Gamble: Nope. There is a character named Sera Siege though. There are characters named after everyone on the staff. The episode starts out dizzyingly meta: Sam and Dean discover a book series called Supernatural, about the adventures of two demon-hunting brothers named Sam and Dean. Every detail is spot-on. Obviously, this is deeply alarming to them. Julie Siege wrote the episode, and she was very even-handed, in that she managed to take hilarious jabs at the writers, the fans and the boys. The story eventually twists in an unexpected direction that's more grounded and substantial — it's not just an amusing exercise. But if there was any doubt that we have a sense of humor about ourselves, this ought to clear it up. 

What is the difference (besides what I guess you could call their "political" affiliations") between the angels and demons? I ask because their policies seem to be pretty similar: Both sides are into possessing humans; both sides are into destroying large numbers of humans and both sides are willing to do extreme measures with no regard for the suffering of others to achieve their objectives. — MrKWoodmaid
Gamble: Their methods are often eerily similar, huh? I find that pretty interesting. One big difference is that demons used to be human. Angels never were. Demons may have lost their humanity, but it could be argued that angels never had it to begin with. But: It's not entirely true that angels have no regard for the suffering of humans. Castiel is clearly troubled by it. Anna was so compelled by humans that she chose to fall. You've got to take angels on a case-by-case basis. 

Does Sam know what his mother did? Related to that, will we ever get to see Sam interact with his mother in some fashion? Or perhaps get some insight on how he feels about her or his father? — CharlotteJane
Gamble: Dean told Sam all about the events he witnessed in "In The Beginning," yes.  We alluded to that in the following episode. Further insight into how Sam feels about his folks: yes. We get into that on more than one occasion. As for actually seeing Sam interact with his mother: can't promise quite yet, but Vegas money is on yes. 

Even though Episode 9 explained why Ruby was so different this season, can we expect further explanation? — Kerri-Ann
Gamble: I'll keep it general — 'cause I can't really be more specific without violating the terms of my Ruby Nondisclosure Agreement — and just say that there is more to come regarding Ruby, the change in her attitude and her relationship with Sam. 

Will there ever be an episode about the Jersey Devil? — irishgirl
Gamble: Not this season, so visit your local wishing well and petition for a Season 5. 

Are we going to get a "Headless Horseman" episode anytime soon? That would be a great urban legend to cover. — Freyja
Gamble: It's on the master list of urban legends, and comes up periodically. No time this season. Hit up that wishing well again! 

Will DemonMeg, Ellen, Lilith, Alastair or Anna be back anytime soon? — BradleyL317
Gamble: Yup, you'll be seeing Alastair and Anna again soon. And Lilith will be making a reappearance later this season as well. 

Dean always seems to get the mystical journeys, from "What Is and What Should Never Be" to "Dream a Little Dream of Me" and "In the Beginning." Will Sam ever get a chance to really get inside his soul and see what lies within it? — coolguypadalecki
Gamble: Oh, yes. Episode 421. I'm searching my brain for a more intense word for "intense." 

Watch clips from this week's "After School Special" episode here, here and here.

(Additional reporting by Tina Charles)