Robert Wisdom with Misha Collins, Supernatural

A witch. Halloween. The possible unleashing of Satan. Sounds like a case for the Winchester boys and their winged wingman. Tonight on Supernatural (9 pm/ET, the CW), even Castiel agrees that heavy artillery is called for. Cue guest-star Robert Wisdom, as an angel with 'tude. The former Wire star shared a look at this hellish holiday outing. Plus: His take on "the greatest show that's ever been on American television."

TVGuide.com: I'm guessing — purely guessing —  that this is the first angel you've played.
Robert Wisdom:
[Laughs] Well, there aren't too many I've been offered, but this is the first one, yeah.

TVGuide.com: What brings Uriel to the world of Supernatural? Is he there to ostensibly save Halloween?
Wisdom:
Yes, that's my job, and it's a big one. It's a real sweet role. They've written some really powerful stuff. I like the show.

TVGuide.com: I'm thinking he doesn't get a big ol' hug from Castiel?
Wisdom:
No, we are kind of a mix between characters from the Addams Family realm and The Odd Couple. [Laughs] We like each other but we aren't real close.

TVGuide.com: They have different approaches to the job, I understand.
Wisdom:
Uriel basically uses power to get the job done. If that means smiting a whole city, he has to do it.

TVGuide.com: Misha Collins told me that Uriei is a bit "trigger-happy."
Wisdom:
I wouldn't say trigger-happy, but he's "eager" to carry out God's will.

TVGuide.com: So, he's closer to Prison Break's Lechero than The Wire's Bunny.
Wisdom:
Oh, by far. By far. [Laughs]

TVGuide.com: How did you like working with Jensen Ackles and Jared Padalecki?
Wisdom:
They're both great guys, and they're funny as all get out. Jared is a cut-up, and Jensen is a real fine man. In this episode, we have quite a bit of work together.

TVGuide.com: Is the door left open for your character to return ... or not so much?
Wisdom:
Angels can always come and go. It's a permeable wall between our worlds, so there's a possibility he could show up again.

TVGuide.com: Was filming up there in Vancouver more comfortable than Prison Break's "Panama"?
Wisdom:
Autumn is a great time to be in Vancouver, and Dallas was... hot. We were seriously hot. We shot on this red clay set that just kept heat. We had a great time, but it was hellish. This was a lot more pleasant, for sure.

TVGuide.com: All of your Prison Break scenes looked grueling, hot and/or odorous.
Wisdom:
Well, then we pulled it off! It's all done with a squeegee bottle and a lot of Vaseline.

TVGuide.com: What will you most fondly remember about The Wire?
Wisdom:
Oh, my god.... I have to say, I've loved all the jobs and everybody I've worked with, but that's one of a kind, a once-in-a-lifetime experience. You can get it on a film [set], but on a TV series...?

TVGuide.com: What do you think the show's legacy should be?
Wisdom:
From the feedback I get every day, it's the greatest show that's ever been on American television.