Shirley MacLaine and Oprah Winfrey

What do we know for sure? That Oprah Winfrey has some spectacular guests lined up for Season 5 of Super Soul Sunday! The spiritually based OWN programming block will return March 23 (11 a.m./10c) with a slate of all-new Winfrey interviews. First up is Oscar winner Shirley MacLaine who will discuss her latest book, What If...: A Lifetime of Questions, Speculations, Reasonable Guesses, and a Few Things I Know For Sure. After decades of spiritual seeking, MacLaine will share why asking one simple question can open up a world of wonder.

Other Season 5 guests include media mogul Arianna Huffington, time-lapse cinematographer Louie Schwartzberg, TV writer and relationship expert Tracy McMillan, spiritual teacher Adyashanti, Omega Institute cofounder Elizabeth Lesser and bestselling authors Gary Zukav, Shawn Achor and Sue Monk Kidd.

The MacLaine interview will be immediately followed by the television premiere of Super Soul Sunday Presents Oprah & Eckhart Tolle: A New Earth (12 p.m./11c), Winfrey's wildly successful 2008 web series based on Tolle's landmark book A New Earth: Awakening to Your Life's Purpose. Already viewed in 40 million homes, the 10-week series — which now includes brand-new content — has Winfrey and Tolle connecting with viewers worldwide via Skype, email and telephone with practical advice on how to become more aware and present in the moment and how to bring peace and joy into our stressful lives. A truly global classroom!

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