Ryan Reynolds

Time to walk the plank, Johnny Depp: Ryan Reynolds is People's Sexiest Man Alive for 2010.

Check out photos of Ryan Reynolds

"The most difficult part is going to be organically working this title into a conversation with random strangers," the actor tells the magazine.

The 34-year-old follows in the footsteps of such past Sexiest honorees as Sean Connery, Ben Affleck, Matt Damon, Hugh Jackman, Brad Pitt, George Clooney and last year's pick, Depp. Pitt, Clooney and Depp are the only two-time recipients.

Reynolds, who's already showed off his buff bod in Blade: Trinity and X-Men Origins: Wolverine, will next suit up as the Green Lantern. "My body naturally wants to look like Dick Van Dyke," he says. "When I stop training, I turn into a skin-colored whisper."

Watch videos of Ryan Reynolds

Reynolds isn't the only one in his household with a hottie magazine title to his name: His wife, Scarlett Johansson, was recently named GQ's Babe of the Year.

"Now it's going to be, 'Sexiest man, take out the garbage,'" Reynolds jokes of his new home life. "That does sound better."

Other honorees on this year's list include Jon Hamm, Matthew Morrison, Joe Manganiello, Robert Downey Jr., Justin Timberlake, Vin Diesel and Jake Gyllenhaal.

What do you think of People's pick?