Sandra Bullock left the Southern California house she shares with Jesse James just days before a report of infidelity by her husband surfaced, People reports.
The Oscar winner left on Monday, a source told the magazine. On Wednesday, In Touch printed a cover story featuring an interview with tattoo model Michelle "Bombshell" McGee, who claims to have had an 11-month long affair with James while Bullock was filming The Blind Side in Atlanta last year.
See photos of Sandra Bullock
Later on Wednesday, Bullock, 45, abruptly pulled out of the London premiere of The Blind Side, due "to unforeseen personal reasons," according to a statement released by Warner Bros. U.K.
Calls to Bullock's rep were not immediately returned.
Check out photos of Jesse James
Bullock and James, 40, met in 2004 when she brought her godson for a tour of James' Discovery series Monster Garage. The pair married a year later.
James was a fixture at his wife's side this award season as she picked up trophies at the Golden Globes, the Screen Actors Guild Awards and the Oscars for The Blind Side.