Patricia Arquette and Thomas Jane

Medium star Patricia Arquette and her husband, actor Thomas Jane, have filed for divorce after more than two years of marriage.

The pair cited "irreconcilable differences" in their divorce documents, a rep for the L.A. Superior Court told Us. Arquette and Jane met in 2001, got engaged a year later and wed in Venice, Italy, in 2006.

Arquette, 40, is reportedly seeking sole legal and physical custody of their daughter Harlow, 5.

The actress was previously married to Nicolas Cage, while Jane, 39, was previously married to Aysha Hauer. Jane became known for his role in 1999's Deep Blue Sea and as the star of 2004's Punisher.