Amazingly, 80 million American adults had never experienced the joy of Weeds until now. TV Guide Network continues its campaign to build Weeds Awareness and provide hope nationally by airing the award-winning comedy Sunday nights at 9/8c. But with awareness comes responsibility, so TV Guide Network urges viewers to watch Weeds while considering the impact of marijuana.  Here are some of the most memorable anti-drug PSAs of all time:

1. YOUR BRAIN ON DRUGS

TV Guide named this as one of the top 100 television advertisements, and egg sales went through the roof.



2. WEEDS AWARENESS

National Weeds Awareness Week has its own PSA, which strives to become a future classic.

3.  PEE WEE HERMAN/DON'T DO CRACK

A kitschy man-boy in a bow tie isn't always the voice of reason, but this was before Pee Wee's Big Exposure.



4. TALKING DOG 

A judgmental talking animal who takes himself too seriously? The best PSA to ever air in Narnia!



5.  NINJA TURTLES

Who'd have thought that giant pizza-munching turtles would be teaching kids not to smoke pot?



6.  I LEARNED IT BY WATCHING YOU

If there was ever an anti-pot PSA for the Botwin Family on Weeds, this is the perfect one. 



7.  FLATTENED GIRL

Whoa! Sara looks like a deflated balloon. Stay away from pot and get some helium!



8.  BRAIN ON DRUGS SMASHING

It's a tragedy that Gallagher wasn't hired for this. The man is a natural smasher.



9.  "BE AN ORIGINAL"

Just say No! No to bad hair!  No to cheesy music!  No to yellow suspenders!



10. "DRUGS, DRUGS, DRUGS"

This spot decides which drugs are "good" vs. which are "bad". And if that couple in the commercial had all those kids, fertility drugs must be good.



11.  "STRAIGHT UP!"

The message is clear.  Will Smith and DJ Jazzy Jeff weren't available for this shoot.



12.  MCGRUFF "USERS ARE LOSERS"

Who knew McGruff was so talented at tickling the ivories?



13.  JUST SAY NO

Nancy Reagan came up with "Just Say No", which got her a guest spot on Diff'rent Strokes.  What'chu talkin' 'bout, Nancy!



14.  HANNA BARBERA SCARY TOON

From the same people who brought you Scooby Doo, comes the spookiest trip of all.  Stay away from the Scooby Snacks.



15.  THE MAGICIAN

Who knew that magic was a gateway to drug use?





16. CLINT EASTWOOD/THRILL CAN KILL

Before you pick up that pipe, you got to ask yourself one question: "Do I feel lucky?" Well, do you punk?





17.  GIRL HIGH DIVE

She obviously didn't read the sign: Just say NO DIVING.



18.  BELINDA CARLISLE/LIFE'S A BEACH

Nobody sports an oversized blazer on the beach as well as Belinda Carlisle.





19.  SNAKE-MAN DRUG DEALER

This creepy spot was applauded by humans but hissed by snakes. 



20.  MCGRUFF AND REGINA DUET

McGruff is back with another anti-drug chart topper. Why wasn't he part of "We Are the World"?



21. GIRL ON TRACKS/DO SOMETHING

Can you say metaphor for "train wreck"?



22. FATHER/SON DRUG TALK

A powerful PSA with a serious twist. 



23.  SURFING MONKEY BANKS

Marijuana IS an expensive habit. Think of all the Snuggies that were sold to stoners.



24.  MONSTER KID

The X-Files approach to anti-drug advertising.

25.  COMEDIENNE

This standup routine about basketball player Len Bias is not funny, and that's the point.