Balthazar Getty, Rumer Willis, Anjelica Huston

Medium is stocking up on guest stars for Patricia Arquette's next turn behind the NBC drama's cameras.

Brothers & Sisters' Balthazar Getty, as well as Rumer Willis and Anjelica Huston, will all appear in the special episode, an NBC rep confirmed to TVGuide.com. The episode, entitled "The First Bite is the Deepest" will force Arquette's Allison to deal with the past while facing future consequences.

Huston will reprise her Emmy-nominated role as private investigator Cynthia Keener, who is now in jail for murdering her daughter's killer. Keener comes to Allison for help when a friend (Willis) suddenly disappears. Allison is also called upon by a wealthy real estate developer (Getty) to help him find his missing wife.

Getty was recently reduced to a recurring guest star on Brothers & Sisters. Willis guest-starred on CSI: NY earlier this season.

The episode begins shooting this week and will air in the spring.