Henry Ian Cusick

Now that we know the Man in Black's ultimate game plan on Lost, Henry Ian Cusick says there's no way Desmond will help him destroy the island.

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"Whatever the Man in Black wants, I'm imagining Desmond will want the opposite," Cusick tells TVGuide.com.

Cusick and co-star Nestor Carbonell also discuss the meaning behind Lost, which Carbonell says "is ultimately based on love."

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Check out our video Q&A with them about the series finale of Lost, airing Sunday at 9/8c on ABC: