Jon Cryer, David Letterman

Even after Charlie Sheen called him a troll, Jon Cryer is standing by his former Two and a Half Men co-star.

"I love him," Cryer said on Wednesday night's Late Show with David Letterman. "He's a great friend."

VIDEO: Jon Cryer credits Charlie Sheen for outing him as a troll

Besides a bit on Conan that made fun of Sheen's troll comment, Cryer hasn't said much about the tumultuous past few months when production on the CBS comedy shut down because of Sheen's personal problems. Sheen ultimately was fired after launching a public tirade against the show's creator, Chuck Lorre.

"Nobody in show business can possibly get away with making fun of their boss," Cryer quipped. "It just doesn't happen."

In all seriousness, however, Cryer said Sheen's actions caught everyone off-guard. "We didn't see where it was going," he said. "This has never happened before. It wasn't like back in 1963 everyone remembers when Fred MacMurray went bat s--t and started talking about Freemason ninjas and stuff. It was crazy! And Vivian Vance started urinating on the set of Here's Lucy. ... Nobody was prepared for this."

Jon Cryer "jazzed" about working with Ashton Kutcher

Although Cryer said he remains unaware of the behind-the-scenes decisions to ax Sheen, he and his castmates agree it was for the best. "None of us wanted to continue with the show if we felt like it was hurting him," Cryer said. "And there was a point at which ... I think everybody felt like ... there is no control here."

And even though Cryer said he looks forward to working with new co-star Ashton Kutcher, he still wishes Sheen well. "We want nothing but the best for him," he said. "I want him to get healthy, I want him to stay sober, I want him to be reunited with his family — that would be the best thing."

Watch the full interview: