Joe Biden

Vice President Joe Biden will make his third appearance on The Tonight Show Friday, an NBC rep tells TVGuide.com.  

This will be Biden's first appearance since taking office. He appeared in 2007, and again in 2008 after he accepted the Democratic vice presidential nomination.

Both President Obama and first lady Michelle Obama have also graced Jay Leno's couch.

Tonight Show with Jay Leno Posts Lowest Ratings Since 1992

Adrien Brody and Chris Isaak are also scheduled to appear on Friday's show.