Jennifer Aniston and John Mayer

Looks like John Mayer did get the memo. Or maybe it was Jennifer Aniston who got it. In any case, Mayer and Aniston — who earlier this week asked "Who ever said that every relationship has to last forever?" — have called it quits, People reports.

The news comes two weeks after the couple PDA-ed up a storm at the Oscars — but also after some transatlantic work commitments that may have been the deal-breaker. Aniston had been promoting Marley & Me in Europe, while Mayer worked on his new album in L.A. When Aniston returned, the Grammy winner broke up with her, a source said.

"They had some disagreements and decided to not continue to see each other," said another source. "Jen is moving on with her life like she always does. She seems happy."

This is the second time in a year the duo has split. In August, after a whirlwind four-month romance, Mayer told reporters he and the actress were just Friends again. "I ended a relationship to be alone because I don't want to waste somebody's time if something's not right," he said.

The two were on-again by October after reuniting for several dinner dates.