Jeff Lewis and Jenni Pulos

Not every Interior Therapy couple survived their redesign with Jeff Lewis and his assistant Jenni Pulos.

"We had one particular episode where I knew that this one couple wasn't going to make it," Lewis told TVGuide.com. "By doing exactly what they wanted [I thought], 'They're going to realize that's not the problem,' and it did. They ended up breaking up."

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In the interview below, Lewis and Pulos talk about their latest Bravo series and how they were able to impact many of their clients' lives. Plus: Which house could Jeff not wait to escape?

Interior Therapy with Jeff Lewis airs Wednesdays at 9/8c on Bravo.