Jessica Capshaw and Sara Ramirez

The latest episode of Grey's Anatomy left fans scratching their heads after Callie (Sara Ramirez) announced that she'd be moving with Arizona (Jessica Capshaw) to Africa.

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Long before Callie and Arizona became Calzona, Arizona applied for a grant that she only now ended up winning, which means she'll be moving to Africa. Callie was left struggling with whether or not to tell Arizona how she really felt about the trip.

"Callie [was] caught in that thing where you love somebody so much you don't want to tell them the truth," Ramirez tells TVGuide.com. "Callie really doesn't want to go, but in order to be with Arizona, they decide to go together."

The move to Africa makes it possible for Capshaw, who just gave birth to her second child, to get some time off the ABC medical drama. The void will be filled by guest star Peter MacNicol, who will appear in multiple episodes as a pediatric attending physician working closely with Alex (Justin Chambers).

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Before you think the pair are happily jaunting off to a foreign country, it's not so simple. "It turns into a very rough road," Ramirez says. "Because Callie wasn't very honest from the beginning, it bites her in the butt. She ends up having to be honest about the fact that she really doesn't want to go to Africa, but she's going to go anyway."

Even though Callie agreed to go, the couple's future is in jeopardy. "Arizona and Callie find themselves at a crossroads where Arizona isn't too thrilled with the way things have gone down, and once again we find ourselves at an impasse where we're not sure if they're going to make it."

Do you think Callie and Arizona will make it?