Ellen Pompeo, Sandra Oh

Remember when Cristina and Meredith became each other's person?

Throughout 10 seasons of Grey's Anatomy, Meredith (Ellen Pompeo) and Cristina (Sandra Oh) have developed a relationship that goes beyond BFF status. It's the type of relationship where you cut someone out of a wedding dress, you're by someone's bedside when they wake up after dying, and you help someone deal with the loss of their eyebrows — or worse, their sister (Chyler Leigh).

Grey's Anatomy Gallery: The cast says farewell to Sandra Oh!

This, of course, all makes saying goodbye to Oh that much more difficult: No more twisted sisters! Look back on their best moments from the show below:

What are your favorite Cristina and Meredith moments?

Grey's Anatomy airs Thursdays at 9/8c on ABC.