Mitch Pileggi

Grey's Anatomy has prescribed an encore for X-Files alum Mitch Pileggi.

Pileggi, who first guest-starred on the ABC drama toward the end of Season 3, will return for the two-hour Season 6 premiere, again playing hospital board chairman Larry Jennings, TVGuide.com has learned exclusively.

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When Pileggi first appeared as Jennings, the Seattle Grace bigwig required medical attention after a trip to the Amazon left him with a carnivorous fish lodged in an unfortunate part of the anatomy.

For his encore, Pileggi's hospital mucky-muck will have official business to tend to. It perhaps relates to not one but two staff doctors, Izzie Stevens and George O'Malley, looking the Grim Reaper in the eye.

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Grey's Anatomy's season premiere airs Thursday, Sept. 24, at 9 pm/ET.