David Arquette and Courteney Cox

Between multiple call-ins to The Howard Stern Show and a sit-down with Oprah Winfrey last month, David Arquette has hardly kept quiet about the state of his marriage to Courteney Cox. The two announced they had separated  in October.

In a new interview with Harper's Bazaar, Cox broke her silence and defended her estranged husband and his comments.

Courteney Cox on separation from David Arquette: "This is not like we're getting divorced"

"I'm not saying there wasn't some crazy behavior, but if you know who David is, you know what his intentions are, how honest he is, and how big his heart is," the 46-year-old actress tells the magazine.

The couple, who married in 1999 and have a six-year-old daughter together, separated last year. Soon after, Arquette publicly admitted to sleeping with another woman and entered rehab for alcohol abuse at the start of 2011. He left rehab after a month, and he and Cox remain separated.

David Arquette on Oprah: I had my first beer at 4 years old

"You can't really get mad at David because he's not a malicious person," she says. "He was dealing with things the best way he could. And don't get me wrong, he was on a show for entertainment. David is smart, and David is also a showman. He knew what he was doing."

In his interview with Winfrey last month, Arquette said it would be "ideal" for him and Cox to get back together. " I know that I'll be with her for my whole life," he said. "We have an amazing family together and we're really great parents together."

David Arquette: "I shared too much" on Howard Stern

Cox calls herself his "biggest protector" and said she doesn't think he'll be appearing on Howard Stern again anytime soon. Although she's unsure of what's next in their 11-year marriage, Cox says she still has feelings for Arquette and remains optimistic.

"We loved each other so much, and if anything I feel like we've been extremely successful at marriage. If it doesn't work out, I will have huge waves of pain about failing in that department. But right now I don't have that because I don't know what the future holds and I guess because I have strong feelings for him."

Cox and Arquette will share the screen in Scream 4, which hits theaters in April.