Alex O'Loughlin

Sorry, Moonlight fans: Mick St. John will not be resurrected.

Despite valiant efforts from die-hard fans to bring the beloved but short-lived series back to life on the small or big screen, Alex O'Loughlin says that story is over.

"That's a [executive producer] Joel Silver question, but as far as I know, no. It's done. It's over. Mick St. John has been laid to rest," he tells TVGuide.com.

News: Alex O'Loughlin on his post-Moonlight "tailspin"

That doesn't mean the show's cancellation was painless, especially since Moonlight was "doing well" ratings-wise. "It's a bit of a sad situation, a sad story for me.  Of course, I love that show. I put everything into it. But what are you going to do?" he says. "That's what we do as actors. We put 100 percent into things from the screen test on. It's the most bizarre job in the world: You put 150 percent into it and then you walk away."

The Aussie hunk hasn't walked away from TV or CBS, as his new medical drama, Three Rivers, premieres Sunday at 9/8c. O'Loughlin plays Dr. Andy Yablonski, a preeminent transplant surgeon, on the series, and he hopes his Moonlight fans will hop onboard even without any vampire appearances.

Fall TV: See what Three Rivers is up against

"I'm not exactly sure if that crosses their genre of work!" he says.