Brittany Murphy died early Sunday, TVGuide.com has confirmed. She was 32.
A 911 call came from her home about 8 a.m., according to TMZ.com, which first reported the news. Murphy was transported to Cedars-Sinai Medical Center after going into full cardiac arrest.
She was pronounced dead on arrival at 10:04 a.m., a spokesperson for the hospital told TVGuide.com.
"In this time of sadness, the family thanks you for your love and support," a rep for Murphy said.
Take a look back at Brittany Murphy's TV and movie roles
The actress was 14 when she nabbed her first gig in Hollywood, starring as Brenda Drexell in the series Drexell's Class. Her breakout role came in 1995, when she starred opposite Alicia Silverstone in Clueless. The next several years brought Girl, Interrupted (1999), Don't Say a Word (2001), 8 Mile (2002) and Sin City (2005).
Murphy also lent her voice to the show King of the Hill for 12 years as Luanne Platter. Additionally, she had small roles in various TV series, including Sister, Sister, Party of Five, Blossom, Boy Meets World and Frasier.
Watch videos of Brittany Murphy
In 2006, Murphy and English DJ Paul Oakenfold released the single "Faster Kill Pussycat," which reached No. 1 on Billboard's Hot Dance Club Play chart. The actress also contributed songs to the 2006 film Happy Feet.
One-time boyfriend and co-star, Ashton Kutcher, tweeted: "2day the world lost a little piece of sunshine. My deepest condolences go out 2 Brittany's family, her husband, & her amazing mother Sharon ... see you on the other side kid."
Kutcher weighed in early, then others also followed with expressions of shock and sadness.
"I am in shock that Britney [sic] Murphy has died! Clueless is my all time favorite movie. My prayers go out to her family & husband," Kim Kardashian tweeted.
Eliza Dushku said, "My heart aches having just learned of Brittany Murphy's death. We were friends ... I always admired her pure spirit."
Lindsay Lohan tweeted: "My deepest condolences go out to all of Brittany Murphy's loved ones & may she rest in peace ... She was a great talent w/a beautiful soul xo."
Murphy married screenwriter Simon Monjack in 2007.