ABC will launch a second night of comedy on Tuesdays, led by Tim Allen's Last Man Standing and Man Up, while the splashy, Miami-set remake of Charlie's Angels will anchor Thursdays.
The network's 2011-12 fall lineup also includes new series Suburgatory, Revenge, Once Upon a Time and Pan Am.
Fall 2011 TV Scorecard: Which shows are returning? Which aren't?
Meanwhile, ABC will hold freshmen comedies Apartment 23 and Work It, the Kristin Chenoweth-starring soap Good Christian Belles, and the dramas The River, Missing, and Shonda Rhimes' Scandal for midseason.
Mondays remain the same, led by Dancing With the Stars at 8/7c and the third season of Castle.
Tuesday's big move into comedy begins at 8 with Allen's Last Man Standing, followed by Man Up, a look at what it takes to survive as a modern man as told through the eyes of three best friends. The Dancing results show stays at 9, followed by the Dana Delany medical mystery Body of Proof at 10. Cougar Town and Apartment 23 will air at 9 and 9:30 midseason, respectively, between seasons of Dancing With the Stars.
ABC picks up Charlie's Angels, Tim Allen comedy, Cancels Brothers & Sisters, V
New to Wednesdays is the comedy Suburgatory, about a New York City girl who moves to a cookie-cutter suburban community, at 8:30, and Revenge, a soap opera about a mysterious and vengeful woman played by Brothers & Sisters' Emily Van Camp, at 10. The Middle and Modern Family will remain at 8 and 9, respectively, while Happy Endings will move up to 9:30.
Charlie's Angels, starring Minka Kelly, Rachael Taylor and Annie Ilonzeh as the new angels, will kick off Thursdays at 8, leading into medical mainstays Grey's Anatomy and Private Practice.
Extreme Makeover: Home Edition will move to Friday nights at 8, followed by Shark Tank and the long-running newsmagazine 20/20.
The network will introduce two new hours on Sunday: At 8, Once Upon a Time, starring Jennifer Morrison as a woman who travels to a town where fairy tales are real, and at 10, the serial Pan Am, centered on the intrigues among the stewardesses and pilots of the 1960s' Jet Age. America's Funniest Home Videos and Desperate Housewives continue to anchor 7 and 9, respectively.
Brothers & Sisters, Mr. Sunshine, Detroit 187, Off the Map, No Ordinary Family, Better With You and V have been canceled.
Check out the full schedule:
8 p.m. Dancing With the Stars
10 p.m. Castle
8 p.m. Last Man Standing (new)
8:30 p.m. Man Up (new)
9 p.m. Dancing With the Stars results show
10 p.m. Body of Proof
8 p.m. The Middle
8:30 p.m. Suburgatory (new)
9 p.m. Modern Family
9:30 p.m. Happy Endings (new time slot)
10 p.m. Revenge (new)
8 p.m. Charlie's Angels (new)
9 p.m. Grey's Anatomy
10 p.m. Private Practice
8 p.m. Extreme Makeover: Home Edition (new time slot)
9 p.m. Shark Tank
10 p.m. 20/20
8 p.m. Saturday Night College Football
7 p.m. America's Funniest Home Videos
8 p.m. Once Upon a Time (new)
9 p.m. Desperate Housewives
10 p.m. Pan Am (new)