Alyssa Milano

Alyssa Milano fans will have to wait a little longer to see her headline a new series.

ABC nixed the mid-season comedy, Single with Parents, in which Milano's character balances her dysfunctional family, friends and boss. The network cited "creative differences" with the show's creator, Kristin Newman, and producing team, according to the Reporter.

Single was one of five new series for which ABC ordered pickups in August, but was reportedly delayed several times over its direction, until the ultimate axing.

Three more half-hour comedies are still on tap for the network, including In the Motherhood, Better off Ted and The Goode Family, a cartoon from King of the Hill creator Mike Judge. The Bill Lawrence/Courteney Cox pilot Cougar Town could soon join them on the roster.

Were you already getting warmed up for Milano's new series? Now that Single got the boot, what kind of series do you think she should helm?

Check out clips of Milano's roles over the years with our Online Video Guide.